Aetiological Agent of Rapidly Progressive Glomerulonephritis

Radical progressive glomerulonephritis is a kind of nephritis. According to the serum antibody and immune pathology, the aetiological agent of radical progressive glomerulonephritis can be divided into three types.

Radical progressive glomerulonephritis (hereinafter referred to as radical nephritis) disease is a group of rapid developed the floorboard of the prognosis of severe glomerulonephritis caused by proteinuria, hematuria without urinary urine for renal failure.

Radical progressive glomerulonephritis have a variety of reasons. Generally speaking, radical progressive glomerulonephritis can be divided into two categories: primary and secondary radical nephritis and the secondary radical nephritis in the majority. Having clear onset is usually referred to as secondary radical nephritis, such as secondary to pulmonary hemorrhage - (Goodpasture's syndrome), allergic purpura nephritis syndrome, systemic lupus nephritis, etc. The unknown etiology is called primary radical nephritis. More than half of the primary radical nephritis patients with precursor history of upper respiratory tract infection. Only a few have typical performance of streptococcus infection. Some other patients present a viral respiratory tract infections.

Primary radical nephritis is a kind of immune traumatic diffuse proliferative crescent nephritis. The antigen may be associated with infection, autoimmune, hydrocarbons, etc. According to the serum antibody and immune pathology, the pathogenesis of the disease can be divided into three types:

TypeⅠ, not accompanied by pulmonary hemorrhage type of anti glomerular basement membrane (GBM), for anti GBM antibody combined with GBM antigen activate complement and cause disease. This type often accompanied by anti GBM antibody cycle.

Type Ⅱ, for the immune complex, because the glomerular immune complex deposition or the immune complex formed in situ, activate complement and cause disease. Such patients are often the precursor history of upper respiratory tract infection.

Type Ⅲ, for non immune complex type. 50% ~ 80% for the patients with kidney microvascular inflammatory. the kidney is affected first and even the only affected organ, or even damage to coexist with other systems. Primary small vasculitis patients serum anti neutrophil cytoplasm antibodies (ANCA) positive.

These are the introduction of aetiological agent of radical progressive glomerulonephritis.if you still want to know more about radical progressive glomerulonephritis or kidney disease, please consult our online kidney disease exports for free help.