What is IgA Nephropathy，What are the causes of IgA Nephropathy

What is IgA Nephropathy

IgA Nephropathy, also known as Berger's disease, is a kind of primary glomerular nephritis characterized by deposition of IgA or IgA antibodies in glomerular mesangial areas. Common clinical manifestations mainly includes frequent or recurrent hematuria and protein in urine. Severe high blood pressure is also seen in some cases. If not treated properly, the disease will develop into chronic kidney failure.

What are the causes of IgA Nephropathy

IgA Nephropathy is generally accepted as a glomerular disease caused by the deposition of immune complex. Its occurrence is associated with the following factors:

1.Immune system disorders. IgA nephropathy is mainly caused by the deposition of Polymer IgA in the glomeruli and this indicates disorders of the IgA immune system.

2.Bone morrow disorders. The IgA depositing in the kidneys is bone marrow-derived.

3. Abnormal cellular inflammatory factors. The IgA1 in the mesangial areas will cause the mesangial cells to secrete inflammatory factors and cause extreme inflammatory reaction resulting in damages of renal structure and renal function.