Whether the Stem Cell Transplant is effective for the Diabetic Nephropathy

Clinic practice shows that the incidence of the Diabetic Nephropathy increases with the duration of Diabetic. The Diabetic disease in the early stage is showing that the kidney are being a high filtration because of its size enlarged, its glomerulus filtration increased, then gradual onset of interstitial proteinuria and microalbuminuria. With the extension of Diabetic disease course, protein urine, edema, hypertension and the decreased rate of glomerulus filtration would be occurred, then continuous the Renal Insufficiency and Uremia. These are the main causes of death of diabetes. The Diabetic patients have a high glucose in blood, while the glucose is like sediment in the river, when it is flowing through the kidney it can easily adhere to the strainer, make the kidney harder, narrower, obstructed and even destructed. All of these changes are in quietly process, therefore, the Diabetes is like “sugar-coated bomb” which is quietly entering into the kidney. The Diabetic Nephropathy patient should pay attention to the control of glycemic. If this disease treated well in early stage, it can be reversed. Or it cannot be reversed once it is in the stage of clinical albuminuria. Therefore, initial prevention is very important which also require the diabetic nephropathy pay attention to the control of glycemic. The Diabetic Nephropathy patients must pay attention to glycemic control. Hyperglycemia can promote the sodium reabsorption of kidney, which adds extracellular fluid volume, increases releasing of Atrial Natriuretic Factor (ANF). The ANF augments glomerular anterior vessels, constringes glomerular posterior vessels, which lead to form Renal Hypertransfusion and High Filtration; advanced Glycosylation end products can lead to increasing of glomerular basement membrane and mesangial matrix, and then damage the renal structure and function. However, urinary albumin is extremely relevant to the control quality of glycemic, and strict control of glycemic is the key point for preventing and reducing initial diabetic nephropathy. Excessive intake of protein, especially vegetable protein with bigger molecules can aggravate the damage of renal filtration and accelerate the glomerular capillary sclerosis. Although low protein is conducive to protect the kidney, and this diet is too early for the initial diabetic nephropathy therapy. Is stem cell transplant is effective for the diabetic nephropathy? The conventional therapy must be combined with the later treatment. With the development of medical science, stem cell transplant is applied to the therapy of diabetic nephropathy.

Treatment of Diabetic Nephropathy

The main diagnostic base of clinical diabetic nephropathy is proteinuria. If the factors, such as urinary infection, diabetic ketoacidosis, heart failure, glomerulonephritis, can be excluded, it’s more likely to be diabetic nephropathy. DN still has no effective therapy. The treatment principles are:1. To strictly control blood sugar to make the blood sugar close to the normal level, and prevent and delay the occurrence of DN; 2. to delay the rate of kidney function decrease;3.to treat with dialysis or kidney transplant. 1. To strictly control glucose. Before occurring to clinical DN, use insulin pump or multiple subcutaneous insulin injection to control Diabetic Mellitus and keep the glucose the normal level, which can delay even prevent the occurrence and development of DN. It is good for other complications to lower the increasing GFR and improve microalbuminuria. According to The Diabetes Control and Complications Trial(DCCT) study, T1DM treated with insulin intensive treatment can reduce by 35%-55% of the occurrence rate for DN. Controlling glucose for the patients having developed into clinical DN and having obvious proteinuria is less useful for disease development. Hypoglycemic drugs will change into insulin after occurring to Clincial DN. 2. To control hypertension. Hypertension can accelerate the development of Renal Failure. The effective hypotensive treatment can slower the speed of GFR reduction and decrease the output of urinary albumin. Angiotensin coverting enzyme inhibitor or angiotensin Ⅱ receptor antagonist can be the first choice, and often used together with other hypotensive drugs, such as calcium antagonists, diuresis, β adrenergic receptor, methyldopa, and clonidine. If patients’ pressure is more than ≥130//80mmHg 3. Limit in protein intake. Proper reducing protein intake in food can decrease the intraglomerular pressure, high filtration and proteinuria. In contrast, high protein food may aggravate glomerular histological lesion. Patient with renal insufficiency should strictly control protein intake and take high quality protein containing essential amino-acid. 4. Dialysis and kidney transplantation。 Once patients progress to renal failure, the only effective ways are dialysis and kidney transplantation. Kidney transplantation is the best treatment for diabetic nephropathy, prior to dialysis. But for the patients over age of 65, the after-transplantation effect is poor.

How to Prevent the Occurence of End-Stage Renal Failure (ESRF)

Patients with Polycystic Kidney Disease (PKD), Diabetes, hypertension, Nephrotic Syndrome, glomerular nephritis, frequent urinary tract infections (UTI), etc, are all susceptible for end-stage kidney disease. End-stage kidney failure patients may need to go dialysis or do kidney transplantation to sustain life. If we want to prevent the occurrence of end-stage renal failure, we need to be sure of some warning signs of kidney injuries: 1. Edema in eyelids, ankles, face, lower limbs, etc. Usually, protein loss in urine will go hand in hand with edema in kidney disease patients. Severe edema can result in short breath. 2. Frequent urinations at night, which is detectable if renal tubular reabsorption ability is damaged. 3. Foams or bubbles in urine which don′t disappear for a long time- this is a warning sign for protein loss caused by impaired glomerular filtration membrane. 4. Anemia. Anemia will happen as the kidneys can no longer produce enough erythropoietin- a hormone that promotes production of red blood cells. Patients will often feel very overfatigued. 5. Toxins such as creatinine and blood urea nitrogen levels increase gradually in blood, so the patient will have the following symptoms: Symptoms in digestive tract: poor appetite, vomiting and nausea; Poor sleeping quality Skin itching 6. Decreasing urine output. A main function of kidneys is to remove excess water from the body. With gradual loss of functioning kidney function, patients will find themselves making less and less urine. If you have some of the above symptoms, it is necessary to do full check-ups about your kidney condition. There are actually many inducing factors for kidney diseases. All in all, early detection, proper treatment and careful nursing measures protect you from entering end-stage kidney failure. Do you have any other questions? You can send an email to the experts in Funeng Kidney Disease Hospital,or you also can call the phone number directly. Our experts will reply you as soon as possible.

Fruits for the Patients with Kidney Disease

Eating a balanced diet is important for good healthy, especially for people with Kidney Disease. As fruits contain abundant vitamins, the patients are often recommended to eat more fruits in their daily diet. However, some fruits may contain substances that can aggravate kidney function. Therefore, the patients with Kidney Disease should know what fruits are beneficial to their health. Here a list of the fruits that benefit to the Kidney Disease patients. 1. Apples Apples are rich in fiber and anti-inflammatory properties. They are helpful in reducing cholesterol level and decrease the incidence of complications like heart disease. 2. Red grapes Red grapes contain several flavonoids. They can prevent oxidation and reduce the formation of blood clots thus decreasing the incidence of heart disease. Moreover, a kind of flavonoid resveratrol in grapes can promote the production of nitric oxide, which can relax the muscle in blood vessels. In this way, it can promote the blood circulation and relive the renal ischemia and anoxia. In addition, the flavonoids can prevent the renal inflammation. 3. Cherries Cherries are abundant of antioxidants that are beneficial in protecting heart. If the patients can eat the fruits daily, it can reduce the renal inflammation. 4. Strawberries Strawberries contain two types of antioxidants and lots of vitamin C and fibers. These integrants in strawberries have anti-inflammation properties and also are beneficial in protecting heart health. 5. Blueberries Blueberries contain compounds antioxidants anthocyanidins and are also abundant of nutrients, vitamin C and fibers. They can reduce the kidney inflammation. Also the manganese in blueberries can contribute bone health. If you are or your loved one is Kidney Disease suffer, you should ask your renal dietitian to make a kidney-friendly diet plan and remove the foods that are bad to your kidneys from your daily food list.

How to Reduce Creatinine and Urea Level

High creatinine and urea level is usually considered as a sign of renal damage which may arouse the nervous of patient to worry about their health, for renal problems may easily develop into renal failure or uremia in a short term. Thereby most patients are seeking an effective method to reduce their high creatinine and urea level. Dietary control Vegetarian and non-greasy diet is a good choice for patients with kidney disease. Creatinine is the waste product of creatine which is resolved for providing energy to contract muscle. And dietary sources of creatine are only fond in animal products, so patients need to avoid the animal foods and go on a light diet. When the body metabolizes protein, the liver makes urea as the end products that will be discharged by kidney through urine. However, decreased ability of impaired kidney is the root cause of high blood urea. Limited protein food can help to reduce the high level of urea, but patients need protein to sustain body’s health. Thereby they should have less food which contains high-quality protein to supply protein to their tissues as well as to avert from product too much urea. Traditional treatment Patients have some options in choosing medicines to reduce the high level of creatinine and urea. Some of medicines may have a good effect to sweep out creatinine and urea through the intestinal tract. Some of them can be combined with other factors in the blood to produce harmless substances to body. But none of them can repair renal cells and tissues in order to filter the creatinine and urea by the kidneys. The new therapy for reducing creatinine and urea We use the most natural medicine---traditional Chinese medicine which can diminish inflammation and provide essential substances to rebuild renal cells. Besides, Chinese medicine can dilate the blood vessels and speed up the blood circulation so as to give more blood and oxygen to the renal tissues, which is favor to the recovery of renal cells. Provided increasing renal functions, kidney will have more ability to filter the toxins easily. Many therapies or methods are supplied for you to choose and your kidney and body health depends on your choice. Would you want to reduce your creatinine and urea level? You can consult our experts online or leave a message below and they will introduce our therapy and give you a hope. If you need our help, contact us by using the form below to send a message to our doctor. You will receive a reply via-email. We are glad to help you!

Will Diabetic Nephropathy be cured

Diabetic nephropathy is the complication of diabetes mellitus, and the death rate is relatively high, so it is very is of great importance to treat the diabetic nephropathy effectively in the early stage, which will be helpful to improve the life quality of the patients with diabetic nephropathy and delay the progress of this disease.

Generally, it is very difficult to cure this disease completely, which need to insist on conservative treatment and insist on the treatment of controlling blood sugar and protecting renal function. Presently, the main treatment of diabetic nephropathy include diet control, following the doctor’ advice to take hypoglycemic agents or to inject insulin and preventing the complication actively. Besides, they should also develop a good living habit and do some exercise. The over-weight patients should keep on a diet and keep the weight back to a normal range. Red Sun nephropathy found the ion-introduction therapy, which is a great-leap-forward development in the clinical treatment of nephropathy and uremia. The biggest advantage of this the therapy is that it could protect the intact nephrons from getting damaged pathologically and save those nephrons that has been damaged but are not totally completely sclerotic and necrotic as well. Thus improve the glomerular filtration rate, restore the kidney function and delay the development of renal failure. If you still have any question, you can communicate with the expert in kidney disease.

Symptoms of Purpura Nephritis

Symptoms of Purpura Nephritis
Purpura nephritis is very common in children, but many people in any ages can be affected. For purpura nephritis is liable to impair kidneys, patients should prevent or block its coming after they have had HSP. So some knowledge about symptoms of purpura nephritis is essential for patients who have had HSP or been at the risk.
The primary symptoms of HSP are purpura, arthritis and abdominal pain, which are bound to appear as a trilogy.
The purple rashes are caused by the bleeding of the capillary in skin, which are presented as small purple spots primarily developing into big or large sheets. Some of the purple rashes are swelling and higher than skin surface. They are spread all over in the body, especially in the face, neck, buttocks and legs.
The arthritis can affect many joint, such as elbow, knees, spine and ankle. When abnormal immune system flares in the joint, the cartilages between the bones are broken down, resulting in joint pain, swelling (inflammation) and stiffness.
Abdominal pain is characterized by a colicky pain, and sometimes may be accompanied by nausea, vomiting and bloody stools. The vasculitis caused by SHP may lead to the swelling of gut, resulting in serious and intermittent pain sometimes due to the intussusceptions (especially in children).
The vasculitis caused by HSP is vital to the damage of renal function. Hematuria and proteinuria are the main signs to predict that inflammation appear in the kidney tissue and destruction takes place. Almost 40% of patients with SHP involve in the kidney disease.
Most patients have evidence of blood in urine (hematuria); while only one forth of patients has this symptom which is not noticeable without special tests. More than half of patients also have proteinuria. If patients miss the best time to treat, the condition may develop more serious. One eight of patient may progress to nephrotic syndrome which is marked by protein in urine, swelling, high cholesterol levels and low blood protein.
All above are the most symptoms of purpura nephritis which is a process that disordered immune system causes a series of vasculitis disease and develops more serious to affect the renal function. Patients should grasp the best time to have an effective treatment in the early stage. Otherwise, the worst stage, uremia may be coming soundlessly. If you have some symptoms, please consult us online.