Whether the Stem Cell Transplant is effective for the Diabetic Nephropathy

Clinic practice shows that the incidence of the Diabetic Nephropathy increases with the duration of Diabetic. The Diabetic disease in the early stage is showing that the kidney are being a high filtration because of its size enlarged, its glomerulus filtration increased, then gradual onset of interstitial proteinuria and microalbuminuria. With the extension of Diabetic disease course, protein urine, edema, hypertension and the decreased rate of glomerulus filtration would be occurred, then continuous the Renal Insufficiency and Uremia. These are the main causes of death of diabetes. The Diabetic patients have a high glucose in blood, while the glucose is like sediment in the river, when it is flowing through the kidney it can easily adhere to the strainer, make the kidney harder, narrower, obstructed and even destructed. All of these changes are in quietly process, therefore, the Diabetes is like “sugar-coated bomb” which is quietly entering into the kidney. The Diabetic Nephropathy patient should pay attention to the control of glycemic. If this disease treated well in early stage, it can be reversed. Or it cannot be reversed once it is in the stage of clinical albuminuria. Therefore, initial prevention is very important which also require the diabetic nephropathy pay attention to the control of glycemic. The Diabetic Nephropathy patients must pay attention to glycemic control. Hyperglycemia can promote the sodium reabsorption of kidney, which adds extracellular fluid volume, increases releasing of Atrial Natriuretic Factor (ANF). The ANF augments glomerular anterior vessels, constringes glomerular posterior vessels, which lead to form Renal Hypertransfusion and High Filtration; advanced Glycosylation end products can lead to increasing of glomerular basement membrane and mesangial matrix, and then damage the renal structure and function. However, urinary albumin is extremely relevant to the control quality of glycemic, and strict control of glycemic is the key point for preventing and reducing initial diabetic nephropathy. Excessive intake of protein, especially vegetable protein with bigger molecules can aggravate the damage of renal filtration and accelerate the glomerular capillary sclerosis. Although low protein is conducive to protect the kidney, and this diet is too early for the initial diabetic nephropathy therapy. Is stem cell transplant is effective for the diabetic nephropathy? The conventional therapy must be combined with the later treatment. With the development of medical science, stem cell transplant is applied to the therapy of diabetic nephropathy.